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產(chǎn)品規(guī)格
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BN40272R-100ul
100ul
￥2360.00
交叉反應：Mouse,Rat(predicted:Human,Dog,Cow,Rabbit,Sheep) 推薦應用：IHC-P,IHC-F,ICC,IF,ELISA
BN40272R-200ul
200ul
￥3490.00
交叉反應：Mouse,Rat(predicted:Human,Dog,Cow,Rabbit,Sheep) 推薦應用：IHC-P,IHC-F,ICC,IF,ELISA
產(chǎn)品描述
| 英文名稱 | RNF111 |
| 中文名稱 | 環(huán)指蛋白111抗體 |
| 別 名 | ARK; Arkadia; DKFZp313E0731; DKFZp686H1966; DKFZp761D081; E3 ubiquitin protein ligase Arkadia; FLJ38008; Ring finger protein 111; RNF 111; RN111_HUMAN. |
| 研究領域 | 細胞生物 免疫學 信號轉(zhuǎn)導 生長因子和激素 泛素 |
| 抗體來源 | Rabbit |
| 克隆類型 | Polyclonal |
| 交叉反應 | Mouse, Rat, (predicted: Human, Dog, Cow, Rabbit, Sheep, ) |
| 產(chǎn)品應用 | ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蠟切片需做抗原修復） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 109kDa |
| 細胞定位 | 細胞核 細胞漿 |
| 性 狀 | Liquid |
| 濃 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human RNF111:851-950/994 |
| 亞 型 | IgG |
| 純化方法 | affinity purified by Protein A |
| 儲 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存條件 | Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. |
| PubMed | PubMed |
| 產(chǎn)品介紹 | The protein encoded by this gene is a nuclear RING-domain containing E3 ubiquitin ligase. This protein interacts with the transforming growth factor (TGF) -beta/NODAL signaling pathway by promoting the ubiquitination and proteosomal degradation of negative regulators, like SMAD proteins, and thereby enhances TGF-beta target-gene transcription. As a modulator of the nodal signaling cascade, this gene plays a critical role in the induction of mesoderm during embryonic development. Alternative splicing of this gene results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2012] Function: Acts in the NODAL pathway of mesoderm patterning during embryonic development. Acts downstream AXIN1 as an E3 ubiquitin-protein ligase which promotes the ubiquitination of inhibitory SMADs such as SMAD7, induces their proteasomal degradation and thereby enhances the transcriptional activity of TGF-beta and BMP. Activates Smad3/Smad4-dependent transcription by triggering signal-induced SnoN degradation. Subunit: Interacts with SMAD6, SMAD7, AXIN1, AXIN2 and SKIL isoform SNON. Part of a complex containing RNF111, AXIN1 and SMAD7. Interacts (via SIM domains) with SUMO1 and SUMO2. Subcellular Location: Cytoplasmic and Nuclear Tissue Specificity: Broadly expressed. Similarity: Contains 1 RING-type zinc finger. SWISS: Q6ZNA4 Gene ID: 54778 Database links: Entrez Gene: 54778 Human Omim: 605840 Human SwissProt: Q6ZNA4 Human Unigene: 404423 Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications |
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