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產(chǎn)品規(guī)格
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BN40213R-100ul
100ul
￥2360.00
交叉反應(yīng)：Human,Mouse,Rat(predicted:Chicken,Dog,Pig,Cow) 推薦應(yīng)用：WB,ICC,Flow-Cyt,ELISA
BN40213R-200ul
200ul
￥3490.00
交叉反應(yīng)：Human,Mouse,Rat(predicted:Chicken,Dog,Pig,Cow) 推薦應(yīng)用：WB,ICC,Flow-Cyt,ELISA
產(chǎn)品描述
| 英文名稱 | GAD65 |
| 中文名稱 | 谷氨酸脫羧酶-65抗體(C端） |
| 別 名 | 65 kDa glutamic acid decarboxylase; DCE 2; DCE2; GAD 2; GAD 65; GAD-2; GAD-65;GAD 65, GAD2; Glutamate Decarboxylase 2 (pancreatic islets and brain 65kDa); Glutamate Decarboxylase 2; Glutamate Decarboxylase 65; Glutamate decarboxylase 65 kDa isoform; Glutamic Acid Decarboxylase 2; Glutamic Acid Decarboxylase 65. |
| 研究領(lǐng)域 | 神經(jīng)生物學(xué) 新陳代謝 |
| 抗體來源 | Rabbit |
| 克隆類型 | Polyclonal |
| 交叉反應(yīng) | Human, (predicted: Mouse, Rat, Chicken, Dog, Pig, Cow, ) |
| 產(chǎn)品應(yīng)用 | ELISA=1:5000-10000 Flow-Cyt=1ug/Test not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 65kDa |
| 細胞定位 | 細胞漿 細胞膜 |
| 性 狀 | Liquid |
| 濃 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human GAD65:501-585/585 |
| 亞 型 | IgG |
| 純化方法 | affinity purified by Protein A |
| 儲 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存條件 | Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. |
| PubMed | PubMed |
| 產(chǎn)品介紹 | This gene encodes one of several forms of glutamic acid decarboxylase, identified as a major autoantigen in insulin-dependent diabetes. The enzyme encoded is responsible for catalyzing the production of gamma-aminobutyric acid from L-glutamic acid. A pathogenic role for this enzyme has been identified in the human pancreas since it has been identified as an autoantibody and an autoreactive T cell target in insulin-dependent diabetes. This gene may also play a role in the stiff man syndrome. Alternative splicing results in multiple transcript variants that encode the same protein. [provided by RefSeq, Oct 2008] Function: Catalyzes the production of GABA. Subunit: Homodimer. Subcellular Location: Cytoplasm, cytosol. Cytoplasmic vesicle. Cell junction, synapse, presynaptic cell membrane; Lipid-anchor. Golgi apparatus membrane; Peripheral membrane protein; Cytoplasmic side. Note=Associated to cytoplasmic vesicles. In neurons, cytosolic leaflet of Golgi membranes and presynaptic clusters. Post-translational modifications: Phosphorylated; which does not affect kinetic parameters or subcellular location. Palmitoylated; which is required for presynaptic clustering. Similarity: Belongs to the group II decarboxylase family. SWISS: Q05329 Gene ID: 2572 Database links: Entrez Gene: 2572 Human Entrez Gene: 14417 Mouse Omim: 138275 Human SwissProt: Q05329 Human SwissProt: Q5VZ29 Human SwissProt: Q5VZ30 Human SwissProt: P48320 Mouse SwissProt: Q548L4 Mouse Unigene: 231829 Human Unigene: 4784 Mouse Unigene: 29951 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. 谷氨酸脫羧酶-65用于I II型糖尿病研究的很重要的蛋白。 |
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